SUZ12 and malignant peripheral nerve sheath tumor: The high prevalence of these tumors, along with their potential for malignant transformation and loss of the SUZ12 gene, part of the NF1 microdeletion region, are predisposing factors that increase the risk of malignant peripheral nerve sheath tumors in patients with large NF1 deletions [30]. Patients with NF1, in addition to visible symptoms, must be closely monitored for associated psychiatric conditions and serious tumors.