PKP2 and arrhythmogenic right ventricular cardiomyopathy: The identified desmosomal gene variants responsible for ARVC include the following: plakoglobin, which affects about 3.8% of ARVC patients; plakiphilin-2 (PKP2), detected in 21%-48.9% of ARVC patients; desmoplakin, carried by 4.4%-14.3% of ARVC patients; desmoglein-2 (DSG2), present in 0.5%-3% of patients with ARVC; and desmocollin-2, observed in 3%-20% of ARVC patients.83