DES and arrhythmogenic right ventricular cardiomyopathy: Nondesmosomal gene variants associated with ARVC include the following: transmembrane protein 43, carried by 0.4%-2.3% of ARVC patients; phospholamban (PLN-p.Arg14del variant), detected in 0.5%-5% of ARVC patients; desmin, with a prevalence of 0.9% in ARVC patients; filamin C, present in 1.8%-3% of ARVC patients; and cadherin-2, which affects < 1% of ARVC patients.83