Further, intervention experiments targeting the key iron metabolism gene HMOX1, including gene knockdown and the use of the HMOX1 inhibitor Zinc Protoporphyrin (ZNPP), observed a restoration in the expression of cell cycle and EMT-related proteins, further strengthening the hypothesis that securinine inhibits gastric cancer cell proliferation and EMT processes by activating ferroptosis mechanisms. The gene discussed is HMOX1; the disease is gastric cancer.