To understand how NK cells respond to ZIKV infection, we profiled NK cell receptor and ligand expression by mass cytometry [18] on PBMCs from a Panamanian cohort of adult ZIKV participants during the acute phase of infection (1–5 days post symptom onset) and post-acute infection (early and late convalescence, 1–6 weeks later) (Table 1: Participant demographics and Table S2). This evidence concerns the gene KLRD1 and Zika virus infectious disease.