PCA based on NES values of the 50 hallmark pathways identified in the patients showed that the GFP-progerin-expressing cell line clustered more closely with HGPS patient cells than WT samples, suggesting that the affected pathways in the progerin cell line are more similar to HGPS than to the WT samples (Fig. S3C). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.