Pathway analysis identified mTORC1 signaling, the UV response, apoptosis, the UPR and TNFα signaling via NF-κB pathways as immediate targets of progerin, and oxidative phosphorylation, Notch signaling and Wnt/b-catenin signaling as adaptive or compensatory pathways affected by long term progerin expression in HGPS patients. The gene discussed is NFKB1; the disease is Hutchinson-Gilford progeria syndrome.