LMNA and Hutchinson-Gilford progeria syndrome: Importantly, the most prominent HGPS pathways, including mTORC1, Notch signaling and the UPR, as well as pathways involved in myogenesis, oxidative phosphorylation, apoptosis, inflammatory response, ROS production, DNA repair and angiogenesis were upregulated in 80–100% of HGPS patients (Fig. 3E, Fig. S2B).