Barcode group 2 uniquely expressed lipid metabolism genes, such as FASN and APOE (Fig. 3G and Fig. S6D; Table S6), which contribute to melanoma resistance by promoting MAPK inhibitor resistance through reducing lipid poly-unsaturation and protecting MITF^low/AXLĥigh persister cells from ferroptosis, respectively23,24. Here, FASN is linked to melanoma.