Many of the B-memory-like binding sites identified to be B-memory-like in U-CLL in this study were shown previously to become hypomethylated between the states of naive and germinal center states of B-cells, and largely retain that hypomethylation through their development into B-memory cells (IRF4, MEF2C, MTA3, BATF, PAX5) (See TF enrichment on their M4 CpG module) [19]. Here, IRF4 is linked to B-cell chronic lymphocytic leukemia.