Whereas antigen-experienced CD8+ PD-1+ cells can be found both in TLS and in the tumor compartment50, PD-1+ TCF1+ CD8+ T cells (which likely corresponded to “precursor of exhausted” or Tpex cells)50 are generally enriched in TLS, where they interact with proliferating B cells (Extended Data Fig. 6d). Here, TCF7 is linked to neoplasm.