Here, we were able to directly compare changes in transcript expression between myotonic (Mbnl1−/−) and non-myotonic (Mbnl1−/−; ClC-1ΔE7a/ΔE7a) DM1 model mice with deep, short-read RNA-seq (150bp paired-end reads; 66.25 ± 8.26 million unique reads (mean ± IQR) mapped to genes with at least 50 supporting reads across all samples) on RNA isolated from quadriceps muscle from 4–6-month-old WT, ClC-1ΔE7a/ΔE7a, Mbnl1−/−, and Mbnl1−/−; ClC-1ΔE7a/ΔE7a mice (n=4 mice/genotype). This evidence concerns the gene CLC and myotonic dystrophy type 1.