Next, to directly assess the proportion of genes dysregulated in Mbnl1−/− muscle that have expression levels closer to WT in the absence of myotonia (i.e., in Mbnl1−/−; ClC-1ΔE7a/ΔE7a samples), we completed pair-wise differential expression analysis between Mbnl1−/− and WT samples as well as Mbnl1−/−; ClC-1ΔE7a/ΔE7a and WT samples, then compared the resulting gene sets. Here, MBNL1 is linked to Myotonia.