MTOR and neoplasm: Furthermore, the enrichment of neutrophils in Tp53Indel/Pik3caH1047R and Nf1Indel/Tp53Indel/Pik3caH1047R tumors may reflect enhanced mTOR signaling (“group 4” in Fig 3), consistent with the role of mTOR in promoting systemic neutrophil accumulation and tumor infiltration45.