Notably, PDLIM2 restoration by nano-delivery of exogenous PDLIM2 (nanoPDLIM2) or pharmacological induction of endogenous PDLIM2 shows promising therapeutic activities and improves the efficacy of chemotherapy and immunotherapy in the mouse models of lung cancer [7, 8, 10, 15]. This evidence concerns the gene PDLIM2 and lung carcinoma.