Importantly, PDLIM2 repression is associated with aberrant activations of numerous common or cell type-specific signaling pathways, e.g., downregulation of the IL-10, RhoGDI, and PPAR signaling pathways in most cell types, whereas excessive activation of NF-κB, STAT3, cellular stress, senescence, immunogenic cell death, and pathogen-induced cytokine storm signaling pathways in all or most of those cell types, NETosis in neutrophils, and pulmonary fibrosis in fibroblasts. Here, ARHGDIA is linked to pulmonary fibrosis.