In contrast, in primary tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), LL-T-1–1 robustly stained all hallmark tau inclusions—including tufted astrocytes, coiled bodies, and astrocytic plaques—highlighting its broader utility in tauopathy diagnosis beyond AD. Here, MAPT is linked to Alzheimer disease.