In contrast, in primary tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), LL-T-1–1 robustly stained all hallmark tau inclusions—including tufted astrocytes, coiled bodies, and astrocytic plaques—highlighting its broader utility in tauopathy diagnosis beyond AD. This evidence concerns the gene MAPT and progressive supranuclear palsy.