Knockout of the SRPK3 orthologue in zebrafish causes cerebellar atrophy and abnormal eye movement, phenotypes that resemble clinical features found in human intellectual disability17, whilst SRPK phosphorylates the E3 ubiquitin ligase RNF12/RLIM, which is mutated in the X-linked intellectual disability disorder Tonne-Kalscheuer syndrome (TOKAS)7,22,23. This evidence concerns the gene RLIM and Cerebellar atrophy.