While reports of reduced penetrance for the NM_003001.5:c.377A>G; p.(Tyr126Cys) variant in SDHC (HGNC:10682) were not identified, this variant is relatively rare in pheochromocytoma/paraganglioma cohorts but has the highest gnomAD Grpmax FAF for ClinVar SDHC P/LP variants [13]. This evidence concerns the gene SDHC and hereditary pheochromocytoma-paraganglioma.