The Angelman syndrome and Prader-Willi syndrome imprinted domain cluster is in the same genomic region, where the antisense RNA (Ube3a-ATS) originates from the paternal Snrpn promoter involved in the imprinting setting of the Ube3a paternal allele in the brain70. The gene discussed is SNRPN; the disease is Prader-Willi syndrome.