This antitumor activity was linked to the suppression of TNF-α-mediated NF-κB and lysophosphatidic acid–autotaxin (LPA–ATX) signaling pathways, resulting in effective inhibition of distant metastasis (95).In the context of clinical depression management, a randomized controlled trial evaluated the efficacy of infliximab in 60 patients with treatment-resistant depression (TRD), using high-sensitivity C-reactive protein (hs-CRP >5 mg/L) as an inflammatory stratification marker. This evidence concerns the gene ENPP2 and major depressive disorder.