Additionally, PI3K/AKT signaling stimulates protein synthesis and cell growth via activation of the mammalian target of rapamycin (mTOR) (52), and promotes cell survival through NF-κB activation (53).Consequently, elevated IL - 6 levels associated with depressive states induce hyperactivation of the PI3K–AKT pathway, thereby substantively contributing to tumor progression. The gene discussed is NFKB1; the disease is neoplasm.