TNF-α, IL - 1β, IL - 6, and IL - 17 each demonstrated significant positive correlations with HADS-A scores (P < 0.05), the prevalence of anxiety (P < 0.05), HADS-D scores (P < 0.05), and the incidence of depression (P < 0.05 for all) (107). The gene discussed is TNF; the disease is major depressive disorder.