Sustained activation of the MEK/ERK signaling axis is capable of transforming normal cells into a malignant phenotype, whereas inhibition of this pathway can revert tumor cells to a non-transformed state in vitro and effectively suppress tumor growth in vivo (47).The MAPK/ERK pathway also contributes to the regulation of the cell cycle, particularly during the transition from G1 to S phase (48). Here, MAP2K7 is linked to neoplasm.