There was also a positive correlation between the expression level of TNF-β and the number of CMBs in deep (β = 0.314, 95% CI:2.989-39.461, P = 0.023) and lobar region (β = 0.433, 95% CI:15.363-59.857, P = 0.001) after adjusting for age, sex, history of hypertension and history of diabetes. The gene discussed is LTA; the disease is hypertensive disorder.