The expression level of TNF-β was also associated with MMSE (β = -0.281, 95% CI:-5.325–0.866, P = 0.008) and apathy scores (β = 0.388, 95% CI:2.554-16.328, P = 0.008) after adjusting for age, sex, educational years, history of hypertension and history of diabetes. This evidence concerns the gene LTA and hypertensive disorder.