For instance, elevated NET biomarkers, such as myeloperoxidase-DNA (MPO-DNA) complexes, Neutrophil Elastase (NE), and citrullinated histone H3 (citH3), are observed in preeclampsia and spontaneous preterm birth, correlating with placental inflammation and vascular dysfunction (6, 9, 10). This evidence concerns the gene MPO and preeclampsia.