Further experiments are needed to characterize the phenotype of peripheral blood iNKT cells from patients with obesity, including analyses of proliferation, cytotoxic function, downstream TCR signaling pathways (e.g., Mitogen-Activated Protein Kinase, MAPK) and the expression of anergy-associated genes following α-GalCer stimulation (41). The gene discussed is WNK2; the disease is obesity disorder.