PFKFB3 and neoplasm: However, by delivering fructose −1,6- diphosphate (F16bp, downstream product of PFKFB3), the glycolytic ability and function of DCs can be “saved”, the anti-tumor response of activating cytotoxic T cells (Tc) can be enhanced, and the survival of mice can be improved (Inamdar et al., 2023).