OPA1 and diabetic cardiomyopathy: Downregulation of Mfn2 exacerbates diabetic cardiomyopathy (Hu et al., 2019), and recent studies have shown that brain natriuretic peptide (BNP) protects against diabetic cardiomyopathy by promoting OPA1-mediated mitochondrial fusion through activation of the PKG-STAT3 pathway (Chang et al., 2023).