INS and Other metabolic disease: Moreover, pancreatic beta‐cell insulin secretion relies on mitochondrial Ca2+ uptake, which links glucose metabolism to ATP production and triggers Ca2+‐dependent exocytosis of insulin, a process that is strongly affected by age‐related alterations in mitochondrial Ca2+ homeostasis, potentially serving as a trigger for the development of metabolic diseases like type 2 diabetes mellitus (Mammucari et al. 2018).