TNF and Sepsis: In an LPS‐induced sepsis model, ectosomes enriched with wild‐type Calhm6 (Ecto‐Calhm6WT), but not loss‐of‐function Calhm6E119R (Ecto‐Calhm6E119R) or empty‐vector control (Ecto‐EV), improved survival (Figure 5L), reduced lung pathology (Figure 5M), suppressed systemic IL‐6/TNF‐α/IL‐1β levels (Figure S5K, Supporting Information), and decreased organ injury markers including creatinine (CRE), blood urea nitrogen (BUN), alanine transaminase (ALT), and aspartate transaminase (AST) (Figure S5L, Supporting Information).