In an LPS‐induced sepsis model, ectosomes enriched with wild‐type Calhm6 (Ecto‐Calhm6WT), but not loss‐of‐function Calhm6E119R (Ecto‐Calhm6E119R) or empty‐vector control (Ecto‐EV), improved survival (Figure 5L), reduced lung pathology (Figure 5M), suppressed systemic IL‐6/TNF‐α/IL‐1β levels (Figure S5K, Supporting Information), and decreased organ injury markers including creatinine (CRE), blood urea nitrogen (BUN), alanine transaminase (ALT), and aspartate transaminase (AST) (Figure S5L, Supporting Information). The gene discussed is IL1B; the disease is Sepsis.