This protein facilitates NK cell activation through synaptic communication, especially during Listeria monocytogenes infections, demonstrating its involvement in innate immune responses.[20, 21] In contrast, our study emphasizes Calhm6's contribution to promoting an anti‐inflammatory M2 macrophage phenotype, which is crucial for resolving inflammation and facilitating tissue repair. This evidence concerns the gene CALHM6 and listeriosis.