IRF3 and autoimmune disease: For instance, the cytosolic DNA‐sensing pathways, including cGAS‐STING and toll‐like receptors, have emerged as key mediators in inflammation, tumors, and autoimmune diseases.[59, 60] Among them, the cGAS‐STING signaling pathway mediates interferon when the cGAS receptor can bind to dsDNA, activating STING and then inducing downstream signals, such as IFN regulatory factor 3 (IRF3).