Moreover, EcNPAQ produces real‐time signals (fluorescence) and therapeutic molecules (lactate dehydrogenase and anti‐PD‐L1nb) to treat hPD‐L1 MC38 tumor in a humanized PD‐1 mouse model and human HT‐29 tumor in a humanized PBMC mouse model. This evidence concerns the gene PDCD1 and neoplasm.