3) The high‐lactate TME induces the activation of PD‐L1 in tumor cells, thereby contributing to tumor cells' protection from targeting by cytotoxic T‐cells.[14, 15] And lactate enhances lactylation of apolipoprotein C‐II protein, thereby leading to regulatory T cell accumulation and immunotherapy resistance.[16] Therefore, researchers employ lactate oxidase or lactate dehydrogenase to effectively reduce TME lactate levels.[17]. This evidence concerns the gene CD274 and neoplasm.