The gene expression in chondrocytes is consistent with that from our previous studies on the role of Piezo1 in the pathogenesis of osteoarthritis in chondrocytes.[34] Our results reveal that Piezo1 deficiency in chondrocytes decreases the expression of osteogenic proteins, and delays fracture healing and DO process, which may be related to the inhibition of endochondral ossification during bone healing. Here, PIEZO1 is linked to osteoarthritis.