SRT2104 (SRT) is a highly specific Sirt1 activator that has been demonstrated to have favorable therapeutic effects on various conditions, such as neurodegenerative diseases, cardiovascular diseases, musculoskeletal diseases, and other diseases.[25] The therapeutic use of SRT is restricted in part due to its poor solubility in water, which largely limits its bioavailability. Here, SIRT1 is linked to musculoskeletal system disorder.