Moreover, the combination of TTM and QNZ synergized to repress human breast tumor growth and promote tumor apoptosis in xenograft mouse models without markedly affecting mouse body weight (Figure 5H–K; Figure S11A, Supporting Information), accompanied by decreased MAPK and AKT activities (Figure 5L), as well as, repress mouse breast tumor growth without markedly affecting mouse body weight (Figure S11B–F, Supporting Information), accompanied with reduced PD‐L1 expression and increased CD8+ cells (Figure S11G, Supporting Information). This evidence concerns the gene AKT1 and breast neoplasm.