Additionally, in MMTV‐PyMT mammary cancer mouse model, the combination of QNZ with TTM efficiently diminished mammary tumor growth and lung metastasis with mild effect on mouse body weight and toxicity to liver or kidney tissues (Figure 6C–H; Figure S13A–E, Supporting Information), accompanied by decreased NF‐κB activity and MAPK/AKT activity (Figure 6F; Figure S13F,G, Supporting Information). This evidence concerns the gene AKT1 and breast cancer.