These findings not only demonstrate the exacerbating impact of EX‐IR‐induced FBXL6high neutrophil on NAFLD, but also confirmed that the functional interaction between FBXL6 and α7‐nAChRs in FBXL6high neutrophil contributes to its deleterious effect. The gene discussed is CHRNA7; the disease is metabolic dysfunction-associated steatotic liver disease.