However, in terms of peripheral regulation, irregular exercise activates the amygdala–DMV–hepatic vagus circuit, increasing hepatic ACh levels and recruiting a novel FBXL6high neutrophil subset, which promotes the interaction of these neutrophils with hepatocytes via Fe to upregulate the COX‐2/5‐LOX‐mediated metabolism of AA in hepatocytes, aggravating rather than alleviating NAFLD in mice. This evidence concerns the gene ALOX5 and metabolic dysfunction-associated steatotic liver disease.