CAF8 Gy‐EV treatment significantly increased mesenchymal markers (Vimentin and Snail) and decreased E‐cadherin expression in KYSE150 and TE‐1 cells (Figure 1H), as well as in metastatic ESCC tumours (Supporting Information Figure 1F), as compared to CAF0 Gy‐EVs treatment, suggesting that irradiated CAF‐derived EVs promote the EMT of ESCC cells. Here, CDH1 is linked to esophageal squamous cell carcinoma.