Notably, three out of the top 10 XIST-correlated genes were histone lysine methyltransferases of H3K4 (KMT2D, KMT2A, KMT2C) and were all positively correlated with XIST. Similar correlations were found in the additional SLE cohorts (Sup. Here, KMT2C is linked to systemic lupus erythematosus.