Further research by Youn et al. revealed the mechanism by which TLR4 upregulates PD-L1 expression in pancreatic cancer cells through the MyD88/NF-κB pathway, and pointed out that blocking the signaling of this pathway can, to a certain extent, inhibit the immune escape process of tumor cells [42]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.