Considering the correlation between LINC00886 and lymph node metastasis, FIGO staging, and patient prognosis, we preliminarily speculate that LINC00886 may regulate immune escape in ovarian cancer through the miR-423-5p/TLR4/Myd88/NF-κB/PD-L1 axis, thereby promoting the malignant development of tumors and influencing patients’ survival outcomes. Here, TLR4 is linked to ovarian carcinoma.