FOXD1 has emerged as a key regulator of stemness in various carcinomas, including colorectal cancer, where it enhances cell stemness to induce chemotherapy resistance via β-catenin [25], and oral squamous cell carcinoma, where it sustains stem cell features by transcriptionally enhancing SNAI2 expression [26]. The gene discussed is SNAI2; the disease is oral cavity squamous cell carcinoma.