Pathway enrichment analysis of differentially epimutated genes revealed significant overrepresentation of key inflammatory pathways, including TNF-alpha signaling via NF-κB and TGF-beta signaling which has been previously implicated in JIA and rheumatoid arthritis (Zhang et al. 2023; Singh et al. 2012; Bira et al. 2005). The gene discussed is TNF; the disease is juvenile idiopathic arthritis.