KLF4 exhibited strong specificity for liver metastases and RUNX1 for lung metastases; at the same time, KLF5, KLF6 and RUNX2 presented signal in both organs, albeit to a different extent, and RUNX3 did not show a tumor-specific signal but rather stained stromal cells in our model (Fig. 7c and Extended Data Fig. 8a). Here, KLF5 is linked to neoplasm.