SMAD4 and neoplasm: Consistent with its organ-specific effects on tumor growth, Smad4 restoration led to upregulation of partially overlapping but mostly distinct genes, as compared to tumor cells kept on Dox: 89% (1,580/1,773) and 74% (613/825) organ-specific genes on days 7 and 14, respectively (Extended Data Fig. 3a and Supplementary Table 1).