SMAD4 and neoplasm: They prominently featured upregulation of the tumor suppressor gene and cell-cycle inhibitor Cdkn1c (also known as p57KIP2)28,29 specifically in the liver, as well as induction of SMAD4’s tumor-promoting fibrogenic program (including Il11, Has2, Serpine1, Col6a1, Itga5, Ccbe1 and Wisp1)24 in both organs, albeit with a delayed kinetics in the lungs (Fig. 3b).