On average, JQ1 treatment decreases BRD4 binding intensity in DLBCL SEs by 85% in 24 h, with SS-to-SE converting regions showing the steepest decrease in magnitude (Student’s t-test \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$P < {10}^{-10}$$\end{document}P<10−10 versus all SEs, Supplementary Fig. 16). Here, BRD4 is linked to diffuse large B-cell lymphoma.