Indeed, in a novel rat model of DS induced by duplication of a selected region of chromosome 20 (parts of the region from Umodl1 to Prmt2) containing the CBS gene, corresponding elevated H2S levels were shown to disrupt gamma-frequency brain electrical activity and suppress the expression of key synaptic proteins, including postsynaptic density protein 95 (PSD-95) and synaptophysin [86]. Here, DLG4 is linked to Dravet syndrome.