In a rat model of Parkinson's disease (PD) induced by 6-hydroxydopamine (6-OHDA), H2S treatment attenuated disease-associated phenotypes, including reductions in dopamine, its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and histone deacetylase (HDAC) activity [63]. The gene discussed is HDAC9; the disease is Parkinson disease.