NFKB1 and systemic lupus erythematosus: Higher levels of the MAP kinases extracellular signal-regulated kinase (ERK) and c-JUN N-terminal kinase early in the disease course have been reported to correlate with organ damage accrual in patients with SLE,38 and BPA treatment of murine macrophages induced ERK phosphorylation together with the activation of NF-κB.39