Using Liver Atlas (29, 30) scRNA cell assignments (to 17unique clusters), we separated the cells assigned to hepatocytes by obesity status (BMI > 35) and aged status (>50 years) and found that both obese and aged group have greater Smsr expression in hepatocytes (P < 0.001). Here, SAMD8 is linked to obesity due to melanocortin 4 receptor deficiency.