Denervation and Fgf21 deletion led to distinct gene expression patterns (Fig. S4A), with overlapping and unique differentially expressed genes (DEGs) identified across four key comparisons: WT denervated vs. WT sham (WD vs. WS), Fgf21KO denervated vs. Fgf21KO sham (KD vs. KS), WT sham vs. Fgf21KO sham (WS vs. KS), and WT denervated vs. Fgf21KO denervated (WD vs. KD) (Fig. S4, B and C). Here, FGF21 is linked to Wilson disease.