ELSA-Brazil, Brazilian Longitudinal Study of Adult Health; USP, University of São Paulo; ICF, Informed Consent Form; CRP, C-Reactive Protein; mL, Milliliter; NOS, Non-Obstructed Smoker; ACO, Asthma-COPD overlap; FMUSP, Faculty of Medicine of the University of São Paulo. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.