CASR and pulmonary arterial hypertension: In the pulmonary arteries of rats with pulmonary arterial hypertension, miR-1249 expression is upregulated, promoting excessive proliferation of pulmonary arterial smooth muscle cells and endothelial cells by inhibiting the HDAC10/NFκB/CaSR cascade, maintaining their anti-apoptotic state, and accelerating the progression of pulmonary arterial hypertension.