In type 2 diabetic mouse models, miR-200b and miR-429 mimics can target and downregulate ZEB1, upregulate COX-2 and MCP-1, increase the expression of inflammatory factors in myocardial tissue, promote myocardial cell apoptosis, and cause myocardial damage, leading to cardiac disease [25]. The gene discussed is ZEB1; the disease is type 2 diabetes mellitus.