In rats with myocardial injury caused by myocardial infarction, the expression of miR-200b-3p and miR-200a-3p is downregulated, and melatonin can regulate the miR-200b-3p/HMGB1 axis to alleviate inflammation and heart failure caused by myocardial infarction [29]. This evidence concerns the gene HMGB1 and heart failure.