The results revealed that the main functional enrichment was negative regulation of microtubule depolymerization, microtubule binding, etc. Pathway analysis focused primarily on the PI3K‒Akt signaling pathway, the MAPK signaling pathway, etc. A literature review revealed that these signaling pathways are indeed closely associated with the onset and progression of hypertension-induced cardiac dysfunction. Here, AKT1 is linked to hypertensive disorder.