As a tumor suppressor, miR-516a-5p targets several genes, including histone cluster 3, H2a, circ MYC proto-oncogene, BHLH transcription factor, and PBX homeobox 3 in non-small cell lung cancer [43], acute myeloid leukemia [44], and HCC [45]. Here, PBX3 is linked to acute myeloid leukemia.