Among these, negative causal associations with RA were observed for AGER (OR, 0.98; 95% CI, 0.98 - 0.99; P = 1.82E-22), while positive causal associations were observed for two proteins: USP8 (OR, 1.01; 95% CI, 1.01 - 1.02; P = 0.031) and IDUA (OR, 1.01; 95% CI, 1.01 - 1.02; P = 0.036). The gene discussed is USP8; the disease is rheumatoid arthritis.