Per SD increase in genetically predicted levels of each protein, the OR of RA ranged from 0.16 (95% CI, 0.12 - 0.21; P = 3.62E-30) for TNF to 2.71 (95% CI, 1.87 - 3.92; P = 2.38E-05) for CEP43. This evidence concerns the gene TNF and rheumatoid arthritis.