Among these, negative causal associations with RA were observed for 10 proteins (AIF1, ARG2, ATP5IF1, CCL19, CDSN, MXRA8, RPA2, SLC16A1, TNF, and TNFRSF14), while positive causal associations were observed for two proteins (CEP43 and PADI2). The gene discussed is CDSN; the disease is rheumatoid arthritis.