Per standard deviation (SD) increase in genetically predicted levels of each protein, the odds ratio (OR) of RA ranged from 0.44 [95% confidence interval (CI), 0.41 - 0.48; P = 7.96E-73] for CFB to 4.50 (95% CI, 4.09 - 4.95; P = 1.51E-203) for HLA-DRA. This evidence concerns the gene HLA-DRA and rheumatoid arthritis.