For 6 of these genes, a role in inflammatory bowel disease is supported by other criteria: GWAS associations with nearby SNPs (ANKRD55, LPP, PDLIM7), experimental perturbation (CCDC50, VCAM1), association with measured protein levels (IL6, VCAM1), or drug effects (IL6, VCAM1). The gene discussed is IL6; the disease is inflammatory bowel disease.