KCNJ2 and obesity due to melanocortin 4 receptor deficiency: Based on the well-known role of VAT in increasing levels of circulating FAs in obesity and the putative capacity of FAs to inhibit Kir2.1, we next aimed to determine whether inhibiting lipolysis in VAT isolated from obese mice could prevent VAT-mediated impairment of endothelial Kir2.1.