The international CFTR2 database from Johns Hopkins University, USA (https://CFTR2.org, accessed 13/2/2025) lists 1085 CF-causing variants, 55 variants of varying clinical consequence, and 27 non-CF-causing variants, while ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/, accessed 13/2/2025) reports 5435 CFTR variants, including 1165 pathogenic variants plus an additional 500 likely pathogenic variants. The gene discussed is CFTR; the disease is cystic fibrosis.