HIF1A and cancer: KEGG pathway analysis of the downregulated DEGs revealed that they were enriched in nine signaling pathways: biosynthesis of amino acids, glycolysis/gluconeogenesis, small cell lung cancer, HIF-1 signaling pathway, RNA degradation, gastric cancer, hepatocellular carcinoma, pathways in cancer, and herpes simplex virus 1 infection (Fig. 2B).