Notably, mature neutrophils in the MG exacerbation group exhibited significant transcriptional heterogeneity, with differential gene analysis showing upregulation of genes such as TNFSF13B, IFIT3, MX1, EPSTI1, PARP14, HERC5, and EIF2AK2 (Figure 4G). The gene discussed is HERC5; the disease is myasthenia gravis.