Notably, mature neutrophils in the MG exacerbation group exhibited significant transcriptional heterogeneity, with differential gene analysis showing upregulation of genes such as TNFSF13B, IFIT3, MX1, EPSTI1, PARP14, HERC5, and EIF2AK2 (Figure 4G). This evidence concerns the gene EPSTI1 and myasthenia gravis.