Mechanistically, HOXA1‐PITX2 complex facilitates the expression of mucolipin 1 (MCOLN1) and RAS‐related protein Rab‐3A (RAB3A), which drive lysosomal exocytosis of galectin‐1 (LGALS1) and insulin like growth factor binding protein 7 (IGFBP7) from senescent gastric cancer cells. The gene discussed is MCOLN1; the disease is gastric cancer.