PITX2 and esophageal squamous cell carcinoma: PITX2, a highly conserved transcription factor of bicoid homeodomain family, plays diverse roles in embryonic development of eyes, teeth, and abdominal viscera.[31] Recent studies show the elevation of PITX2 expression in multiple cancer types, including lung adenocarcinoma (LUAD),[32] colorectal cancer,[33] ovarian malignancies,[34] and esophageal squamous cell carcinoma,[35] which is linked to advanced stages and poor prognosis.[32] Conversely, in prostate cancer, reduced PITX2 expression is associated with poor clinical outcomes,[36] suggesting its context‐dependent roles in tumorigenesis.