Of note, mining of DINIES (https://www.genome.jp/tools/ dinies/),[52] a drug‐target interaction database, reveals additional protein partners of nortriptyline, such as its metabolic enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4),[53] lamin A/C, and monoamine transporters.[54] Thus, future research is needed to explore the impact of nortriptyline on expression profiles (eg. LLPS) or functions of other protein partners, and elucidate its potential off‐target effects in cancer therapy. This evidence concerns the gene CYP3A4 and cancer.