Depleting senescent hepatic stellate cells by dasatinib/quercetin or ABT‐263 is able to inhibit tumor progression.[45] SASP can be also regulated by glucocorticoids, metformin, or Janus kinase inhibitors.[46] In this study, we found that nortriptyline blocked the interaction between HOXA1 and PITX2. This evidence concerns the gene PITX2 and neoplasm.