CCR2 and renal fibrosis: CCR2+ macrophages continue to respond to damage‐associated molecular patterns expressed by injured cells, contributing to the development of renal fibrosis.[28] Linoleic acid, an ω‐6 polyunsaturated fatty acid, when present in excess, promotes the metabolism of related enzymes and consequently induces chronic inflammation.[29] The accumulation of linoleic acid in the kidneys is significant, as it profoundly affects the progression of renal fibrosis.[30, 31] Recent studies have also indicated that linoleic acid exhibits a high affinity for macrophages, promoting inflammatory progression.