Compared to the CKD group, the CKD+NAFLD group had markedly increased vacuolar dilation of renal tubular epithelial cells and a significant increase in blue deposits positive for Masson staining (Figure 1F) and a notable increase in brown α‐SMA immunohistochemical positivity (Figure 1G), which correlated positively with BMI, AST, and ALT levels (Figure 1H–M). This evidence concerns the gene ACTA1 and metabolic dysfunction-associated steatotic liver disease.