Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts, while CCR2+PIRB‐ macrophages secrete PDGFB promoting fibroblast proliferation, leading to the exacerbation of renal fibrosis. This evidence concerns the gene PDGFB and renal fibrosis.