ALOX5AP and metabolic dysfunction-associated steatotic liver disease: Previous studies have shown that ANGPTL8 is highly expressed in steatotic liver cells and binds to PIRB receptors on macrophages, promoting liver injury and fibrosis.[23, 42] However, the interaction between ANGPTL8 and PIRB, as well as its relationship with ALOX5AP and linoleic acid metabolism in mice with NAFLD and concurrent renal fibrosis, has not been thoroughly investigated.