Recent studies have also revealed the involvement of ANGPTL8 in inflammatory diseases, which is consistent with our single‐cell transcriptomic sequencing and untargeted metabolomic analyses.[20] Therefore, we hypothesized that ANGPTL8 plays a critical role in the exacerbation of kidney fibrosis in patients with NAFLD. The gene discussed is ANGPTL8; the disease is metabolic dysfunction-associated steatotic liver disease.