To further confirm whether these macrophages had a CCR2+ background, we performed colocalization detection of CCR2, LILRB2, and ALOX5AP (Figure 10I–K) and confirmed the presence of highly infiltrated CCR2+LILRB2+ macrophages in CKD+NAFLD kidneys with elevated ALOX5AP levels (Figure 10L). This evidence concerns the gene CCR2 and metabolic dysfunction-associated steatotic liver disease.