As a direct homolog of the mouse paired immunoglobulin‐like receptor B (PIRB), the human leukocyte immunoglobulin‐like receptor B2 (LILRB2) also plays a role in liver‐kidney axis function.[43] We found that the protein expression levels of ANGPTL8, LILRB2, and ALOX5AP, which are related to the liver‐kidney axis, were significantly higher in the CKD + NAFLD group than in the CKD group (Figure10A,B). This evidence concerns the gene ANGPTL8 and metabolic dysfunction-associated steatotic liver disease.